HbA1C level is not significantly associated with progression to Proliferative Diabetic Retinopathy in a cohort of Diabetic Nephropathy patients: A Cross-sectional Case Control Study in a type 2 diabetic New Mexican population

Authors

Cody J. Moezzi, University of New Mexico School of Medicine, Albuquerque, NM
Ashley Fitzgerald, University of New Mexico School of Medicine, Albuquerque, NM
Savannah R. Salazar, University of New Mexico School of Medicine, Albuquerque, NM
Rushi Mankad, University of New Mexico School of Medicine, Albuquerque, NM
Clifford R. Qualls, University of New Mexico School of Medicine, Albuquerque, NM
Andrea Cabrera, University of New Mexico, Department of Ophthalmology and Visual Services, Albuquerque, NM
Finny Monickaraj, University of New Mexico, Department of Ophthalmology and Visual Services, Albuquerque, NM; NMVA Health Care System, Albuquerque, NM
Arup Das, University of New Mexico, Department of Ophthalmology and Visual Services, Albuquerque, NM; NMVA Health Care System, Albuquerque, NM

Document Type

Poster

Publication Date

7-14-2023

Abstract

SECTION: Retina (RE)

Purpose: The objective of this study was to examine whether these diabetic retinopathy (DR) and nephropathy (DN) have significant concordance in terms of progression of severity.

Methods: A cross-sectional, case-control study was performed in two cohorts of type 2 diabetic patients in a New Mexican population: Cases had confirmed end-stage renal disease (ESRD; Stage 5, on dialysis, GFR60, n=164). Systemic parameters including HbA1C, blood pressure (BP), lipid levels, serum creatinine (Cr), and retinopathy status by dilated fundus exam were collected by retrospective chart review. Statistical analyses were performed with univariate and multivariate analysis for continuous variables and Chi-squared test for categorical variables.

Results:The majority (65%) of the ESRD cohort had advanced eye disease (proliferative diabetic retinopathy; PDR), while 18% of patients had no/mild eye disease (No DR/ mild non-proliferative diabetic retinopathy; NPDR). Conversely, the mild DN cohort included a significant number of advanced DR (PDR cases) (38%). In the univariate analysis, the development of ESRD was significantly associated with lower HbA1C levels (p

Conclusion: Our findings suggest that there is discordance between progression of retinopathy and nephropathy. HbA1c levels were not significantly correlative with the progression of PDR, suggesting divergent pathogenesis for development of the two microvascular diseases.

Comments

Poster presented at Interprofessional Education Day 2023

Recommended Citation

Moezzi, Cody J.; Ashley Fitzgerald; Savannah R. Salazar; Rushi Mankad; Clifford R. Qualls; Andrea Cabrera; Finny Monickaraj; and Arup Das. "HbA1C level is not significantly associated with progression to Proliferative Diabetic Retinopathy in a cohort of Diabetic Nephropathy patients: A Cross-sectional Case Control Study in a type 2 diabetic New Mexican population." (2023). https://digitalrepository.unm.edu/hsc_ipe_day/9