Metaplasticity in the human motor cortex: validation and comparison of motor outcome measure sensitivity to change
Start Date
8-11-2017 1:30 PM
End Date
8-11-2017 5:30 PM
Abstract
Objective: To validate the methodology of a metaplasticity experimental design by assessingchange in motor excitability after administration of priming transcranial direct current stimulation (tDCS) followed by repetitive transcranial magnetic stimulation (rTMS) inhealthy human participants. Methods: In a randomized, sham-controlled, double blinded crossover trial, we plan to enroll 16healthy participants. Participants will be randomized to priming tDCS in three arms (sham, cathodal or anodal) followed by inhibitory rTMS. Four endpoint measurements will be collected prior to the intervention (M1), immediately after each intervention (M2, M3) and 10 minutes following the rTMS (M4). Results: Preliminary data analysis (n=2) showed enhanced excitation (112% of baseline)following anodal tDCS priming and the expected inhibition restored by rTMS (96%).Cathodal tDCS priming resulted in inhibition (83%) followed by paradoxical increase inexcitation after rTMS (118%). Conclusions: In addition to validating this experimental design as suggested by our preliminary data,we plan to evaluate the sensitivity of motor excitability outcome and behavioral measures. Our future direction is to apply this validated protocol in patient populations to better understand how disease states affect metaplasticity.
Metaplasticity in the human motor cortex: validation and comparison of motor outcome measure sensitivity to change
Objective: To validate the methodology of a metaplasticity experimental design by assessingchange in motor excitability after administration of priming transcranial direct current stimulation (tDCS) followed by repetitive transcranial magnetic stimulation (rTMS) inhealthy human participants. Methods: In a randomized, sham-controlled, double blinded crossover trial, we plan to enroll 16healthy participants. Participants will be randomized to priming tDCS in three arms (sham, cathodal or anodal) followed by inhibitory rTMS. Four endpoint measurements will be collected prior to the intervention (M1), immediately after each intervention (M2, M3) and 10 minutes following the rTMS (M4). Results: Preliminary data analysis (n=2) showed enhanced excitation (112% of baseline)following anodal tDCS priming and the expected inhibition restored by rTMS (96%).Cathodal tDCS priming resulted in inhibition (83%) followed by paradoxical increase inexcitation after rTMS (118%). Conclusions: In addition to validating this experimental design as suggested by our preliminary data,we plan to evaluate the sensitivity of motor excitability outcome and behavioral measures. Our future direction is to apply this validated protocol in patient populations to better understand how disease states affect metaplasticity.
