Methamphetamine (Meth) is a highly addictive and widely abused psychostimulant. Research indicates that the selective 5-HT2A receptor antagonist M100907 attenuates several psychostimulant-induced behaviors, including conditioned place preference (CPP). However, these findings have not yet been extended to Meth. The present study investigated the effects of M100907 on the acquisition of Meth-CPP and Meth-induced anxiety.
Adult male rats were tested using an unbiased two-chamber apparatus across eight consecutive days. Prior to Meth administration, rats were pretreated with M100907 and placed into their initially non-preferred chamber. After four Meth conditioning sessions, the effects of M100907 on Meth-induced changes in CPP were assessed. Following CPP testing, rats were screened for anxiety-like behaviors in the elevated plus-maze.
Pretreatment with M100907 attenuated Meth-induced CPP, blocked Meth-induced increases in anxiety-like behavior and attenuated some indices of anxiety in Meth naïve rats.
Results suggest that blocking 5-HT2A receptors with M100907 attenuates the rewarding and anxiety-inducing effects of Meth.
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Methamphetamine, 5-HT2A, Reward, Anxiety, M100907
Madden, John T.. "Antagonizing serotonin 2A (5-HT2A) receptors attenuates methamphetamine-induced reward and blocks methamphetamine-induced anxiety-like behaviors in adult male rats." (2020). https://digitalrepository.unm.edu/psy_etds/363