Psychology ETDs

Publication Date

Spring 5-18-2020

Abstract

Methamphetamine (Meth) is a highly addictive and widely abused psychostimulant. Research indicates that the selective 5-HT2A receptor antagonist M100907 attenuates several psychostimulant-induced behaviors, including conditioned place preference (CPP). However, these findings have not yet been extended to Meth. The present study investigated the effects of M100907 on the acquisition of Meth-CPP and Meth-induced anxiety.

Adult male rats were tested using an unbiased two-chamber apparatus across eight consecutive days. Prior to Meth administration, rats were pretreated with M100907 and placed into their initially non-preferred chamber. After four Meth conditioning sessions, the effects of M100907 on Meth-induced changes in CPP were assessed. Following CPP testing, rats were screened for anxiety-like behaviors in the elevated plus-maze.

Pretreatment with M100907 attenuated Meth-induced CPP, blocked Meth-induced increases in anxiety-like behavior and attenuated some indices of anxiety in Meth naïve rats.

Results suggest that blocking 5-HT2A receptors with M100907 attenuates the rewarding and anxiety-inducing effects of Meth.

Degree Name

Psychology

Level of Degree

Masters

Department Name

Psychology

First Committee Member (Chair)

Nathan Pentkowski

Second Committee Member

Benjamin Clark

Third Committee Member

Jeremy Hogeveen

Language

English

Keywords

Methamphetamine, 5-HT2A, Reward, Anxiety, M100907

Document Type

Thesis

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