Disrupted dynamic functional network connectivity in fetal alcohol spectrum disorders

Authors

Felicha T. Candelaria-Cook, The Mind Research Network and Lovelace Biomedical Research Institute, Albuquerque, New Mexico, USA
Megan E. Schendel, The Mind Research Network and Lovelace Biomedical Research Institute, Albuquerque, New Mexico, USA
Lucinda Flynn, The Mind Research Network and Lovelace Biomedical Research Institute, Albuquerque, New Mexico, USA
Cassandra Cerros, Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
Dina E. Hill, Department of Psychiatry and Behavioral Sciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
Julia M. Stephen, The Mind Research Network and Lovelace Biomedical Research Institute, Albuquerque, New Mexico, USA

Document Type

Article

Publication Date

3-7-2023

Abstract

BACKGROUND: Prenatal alcohol exposure (PAE) can result in harmful and long-lasting neurodevelopmental changes. Children with PAE or a fetal alcohol spectrum disorder (FASD) have decreased white matter volume and resting-state spectral power compared to typically developing controls (TDC) and impaired resting-state static functional connectivity. The impact of PAE on resting-state dynamic functional network connectivity (dFNC) is unknown.

METHODS: Using eyes-closed and eyes-open magnetoencephalography (MEG) resting-state data, global dFNC statistics and meta-states were examined in 89 children aged 6-16 years (51 TDC, 38 with FASD). Source analyzed MEG data were used as input to group spatial independent component analysis to derive functional networks from which the dFNC was calculated.

RESULTS: During eyes-closed, relative to TDC, participants with FASD spent a significantly longer time in state 2, typified by anticorrelation (i.e., decreased connectivity) within and between default mode network (DMN) and visual network (VN), and state 4, typified by stronger internetwork correlation. The FASD group exhibited greater dynamic fluidity and dynamic range (i.e., entered more states, changed from one meta-state to another more often, and traveled greater distances) than TDC. During eyes-open, TDC spent significantly more time in state 1, typified by positive intra- and interdomain connectivity with modest correlation within the frontal network (FN), while participants with FASD spent a larger fraction of time in state 2, typified by anticorrelation within and between DMN and VN and strong correlation within and between FN, attention network, and sensorimotor network.

CONCLUSIONS: There are important resting-state dFNC differences between children with FASD and TDC. Participants with FASD exhibited greater dynamic fluidity and dynamic range and spent more time in states typified by anticorrelation within and between DMN and VN, and more time in a state typified by high internetwork connectivity. Taken together, these network aberrations indicate that prenatal alcohol exposure has a global effect on resting-state connectivity.

Publisher

Williams And Wilkins

Publication Title

Alcoholism, clinical and experimental research

ISSN

1530-0277

Language (ISO)

English

Recommended Citation

Candelaria-Cook FT, Schendel ME, Flynn L, Cerros C, Hill DE, Stephen JM. Disrupted dynamic functional network connectivity in fetal alcohol spectrum disorders. Alcohol Clin Exp Res. 2023 Mar 7. doi: 10.1111/acer.15046. Epub ahead of print. PMID: 36880528.