Growth Rates of Infants Randomized to Continuous Positive Airway Pressure or Intubation After Extremely Preterm Birth

Authors

Ariel A. Salas, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL
Waldemar A. Carlo, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL
Barbara T. Do, Statistics and Epidemiology Unit, RTI International, Research Triangle Park, NC
Edward F. Bell, Department of Pediatrics, University of Iowa, Iowa City, IA
Abhik Das, Statistics and Epidemiology Unit, RTI International, Research Triangle Park, NC
Krisa P. Van Meurs, Department of Pediatrics, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA
Brenda B. Poindexter, Department of Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, GA
Seetha Shankaran, Department of Pediatrics, Wayne State University, Detroit, MI
Noelle Younge, Department of Pediatrics, Duke University, Durham, NC
Kristi L. Watterberg, University of New Mexico Health Sciences Center, Albuquerque, NM
Rosemary D. Higgins, National Institute of Child Health and Human Development, Bethesda, MD; Department of Global and Community Health, George Mason University, Fairfax, VA
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Document Type

Article

Publication Date

10-1-2021

Abstract

OBJECTIVE: To evaluate the effects of early treatment with continuous positive airway pressure (CPAP) on nutritional intake and in-hospital growth rates of extremely preterm (EPT) infants.

STUDY DESIGN: EPT infants (24

RESULTS: Growth data were analyzed for 810 of 1316 infants enrolled in SUPPORT (414 in the intervention group, 396 in the control group). The median gestational age was 26 weeks, and the mean birth weight was 839 g. Baseline characteristics, total nutritional intake, and in-hospital comorbidities were not significantly different between the 2 groups. In a regression model, growth rates between birth and 36 weeks of PMA, as well as growth rates during multiple intervals from birth to day 7, days 7-14, days 14-21, days 21-28, day 28 to 32 weeks PMA, and 32-36 weeks PMA did not differ between treatment groups. Independent of treatment group, higher growth rates from day 21 to day 28 were associated with a lower risk of having a Bayley-III cognitive score(P = .002).

CONCLUSIONS: EPT infants randomized to early CPAP did not have higher in-hospital growth rates than infants randomized to early intubation.

Publisher

Mosby

Publication Title

The Journal of pediatrics

ISSN

1097-6833

Volume

237

First Page

148

Last Page

153

DOI

10.1016/j.jpeds.2021.06.026

Recommended Citation

Salas AA, Carlo WA, Do BT, Bell EF, Das A, Van Meurs KP, Poindexter BB, Shankaran S, Younge N, Watterberg KL, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Growth Rates of Infants Randomized to Continuous Positive Airway Pressure or Intubation After Extremely Preterm Birth. J Pediatr. 2021 Oct;237:148-153.e3. doi: 10.1016/j.jpeds.2021.06.026. Epub 2021 Jun 19. PMID: 34157349; PMCID: PMC8478787.

Comments

• PMCID: PMC8478787 (available on 2022-10-01)