Tetraspanin CD82 Regulates S1PR

Authors

Chelsea A. Saito-Reis, Department of Pathology, University of New Mexico Health Science Center, Albuquerque, NM, USA
Victoria D. Balise, Department of Pathology, University of New Mexico Health Science Center, Albuquerque, NM, USA
Erica M. Pascetti, Department of Pathology, University of New Mexico Health Science Center, Albuquerque, NM, USA
Magdalena Jiminez, Department of Pathology, University of New Mexico Health Science Center, Albuquerque, NM, USA
Jennifer M. Gillette, Department of Pathology, University of New Mexico Health Science Center, Albuquerque, NM, USA; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USAFollow

Document Type

Article

Publication Date

10-12-2021

Abstract

Hematopoietic stem and progenitor cell (HSPC) mobilization into the blood occurs under normal physiological conditions and is stimulated in the clinic to enable the isolation of HSPCs for transplantation therapies. In the present study, we identify the tetraspanin CD82 as a novel regulator of HSPC mobilization. Using a global CD82 knockout (CD82KO) mouse, we measure enhanced HSPC mobilization after granulocyte-colony stimulating factor (G-CSF) or AMD3100 treatment, which we find is promoted by increased surface expression of the sphingosine 1-phosphate receptor 1 (S1PR

Recommended Citation

Saito-Reis CA, Balise VD, Pascetti EM, Jiminez M, Gillette JM. Tetraspanin CD82 regulates S1PR1-mediated hematopoietic stem and progenitor cell mobilization. Stem Cell Reports. 2021 Oct 12;16(10):2422-2431. doi: 10.1016/j.stemcr.2021.08.009. Epub 2021 Sep 16. PMID: 34534447; PMCID: PMC8514849.