DNA methylation testing with S5 for triage of high-risk HPV positive women

Authors

• Rachael Adcock, Centre for Cancer Prevention, Wolfson Institute of Population Health, Queen Mary University of London, London, UK, Center for HPV Prevention, University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, USA
• Belinda Nedjai, Centre for Cancer Prevention, Wolfson Institute of Population Health, Queen Mary University of London, London, UK
• Attila T. Lorincz, Centre for Cancer Prevention, Wolfson Institute of Population Health, Queen Mary University of London, London, UK
• Dorota Scibior-Bentkowska, Centre for Cancer Prevention, Wolfson Institute of Population Health, Queen Mary University of London, London, UK
• Rawinder Banwait, Centre for Cancer Prevention, Wolfson Institute of Population Health, Queen Mary University of London, London, UK
• Norah Torrez-Martinez, Center for HPV Prevention, University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, USA
• Michael Robertson, Center for HPV Prevention, University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, USA
• Jack Cuzick, Centre for Cancer Prevention, Wolfson Institute of Population Health, Queen Mary University of London, London, UK
• Cosette M. Wheeler, Center for HPV Prevention, University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, USA

Document Type

Article

Publication Date

10-1-2022

Abstract

Methylation of host and viral genes is promising for triage of women with high-risk human papillomavirus infections (hrHPV). Using a population-based sample of hrHPV positive women with cervical biopsies within 12 months after cervical screening, the clinical value of the S5 methylation classifier (S5), HPV genotyping and cytology were compared as potential triage tests, for outcomes of cervical intraepithelial neoplasia (CIN) grade 3 or greater (CIN3+), CIN2+ and CIN2, and the area under the curve (AUC) calculated. S5 scores increased with histopathology severity (P

Recommended Citation

Adcock R, Nedjai B, Lorincz AT, Scibior-Bentkowska D, Banwait R, Torrez-Martinez N, Robertson M, Cuzick J, Wheeler CM; New Mexico HPV Pap Registry Steering Committee. DNA methylation testing with S5 for triage of high-risk HPV positive women. Int J Cancer. 2022 Oct 1;151(7):993-1004. doi: 10.1002/ijc.34050. Epub 2022 May 24. PMID: 35477862; PMCID: PMC9543033.