Prenatal Alcohol Exposure (PAE) and Mild Adolescent Stress Induce Vulnerability to Mild Adult Stress in Mice

Authors

• Justine Zimmerly, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106
• Anette Fernandez-Oropeza, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106
• Melody S. Sun, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106
• Clara J. Tomicek, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106
• Erik J. Balmer, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106
• Noah A. Castro, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106
• Shahani Noor, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106
• Andrea A. Pasmay, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106
• Ariana N. Pritha, University of New Mexico, School of Medicine
• Carlos F. Valenzuela, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106
• Daniel D. Savage, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106
• Erin D. Milligan, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106

Document Type

Poster

Publication Date

3-22-2024

Abstract

This work presents the impact of prenatal alcohol exposure (PAE) on the development of anxiety-like behaviors in adult mice following mild stressors. Models of mild stress in adolescence and adulthood were utilized to unmask aberrant neuroimmune actions and subsequent development of anxiety-like behaviors in adult PAE offspring. The results indicate that PAE induces maladaptive stress responses mediated by neuroinflammatory processes in different brain regions.

Recommended Citation

Zimmerly, Justine; Anette Fernandez-Oropeza; Melody S. Sun; Clara J. Tomicek; Erik J. Balmer; Noah A. Castro; Shahani Noor; Andrea A. Pasmay; Ariana N. Pritha; Carlos F. Valenzuela; Daniel D. Savage; and Erin D. Milligan. "Prenatal Alcohol Exposure (PAE) and Mild Adolescent Stress Induce Vulnerability to Mild Adult Stress in Mice." (2024). https://digitalrepository.unm.edu/hsc-bbhrd/196