Prenatal Alcohol Exposure (PAE) and Mild Adolescent Stress Induce Vulnerability to Mild Adult Stress in Mice

Authors

Justine Zimmerly, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106
Anette Fernandez-Oropeza, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106
Melody S. Sun, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106
Clara J. Tomicek, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106
Erik J. Balmer, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106
Noah A. Castro, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106
Shahani Noor, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106
Andrea A. Pasmay, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106
Ariana N. Pritha, University of New Mexico, School of Medicine
Carlos F. Valenzuela, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106
Daniel D. Savage, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106
Erin D. Milligan, University of New Mexico School of Medicine, Department of Neurosciences, and the New Mexico Alcohol Research Center, Albuquerque, NM 87106

Document Type

Poster

Publication Date

3-22-2024

Abstract

This work presents the impact of prenatal alcohol exposure (PAE) on the development of anxiety-like behaviors in adult mice following mild stressors. Models of mild stress in adolescence and adulthood were utilized to unmask aberrant neuroimmune actions and subsequent development of anxiety-like behaviors in adult PAE offspring. The results indicate that PAE induces maladaptive stress responses mediated by neuroinflammatory processes in different brain regions.

Recommended Citation

Zimmerly, Justine; Anette Fernandez-Oropeza; Melody S. Sun; Clara J. Tomicek; Erik J. Balmer; Noah A. Castro; Shahani Noor; Andrea A. Pasmay; Ariana N. Pritha; Carlos F. Valenzuela; Daniel D. Savage; and Erin D. Milligan. "Prenatal Alcohol Exposure (PAE) and Mild Adolescent Stress Induce Vulnerability to Mild Adult Stress in Mice." (2024). https://digitalrepository.unm.edu/hsc-bbhrd/196