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Glioblastoma is the most common malignant brain tumor in adults. In contrast to several cancers, where the tumor suppressor gene TP53 is altered, most glioblastoma patients retain a non-mutant TP53 gene. However, the survival of these patients is similar to that of mutant patients, suggesting that p53 is nonfunctional. To test this hypothesis, we analyzed data from The Cancer Genome Atlas, identified potential regulators of p53, and we will test their function in patient-derived cells.



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