Dissecting the functional impairment of wild-type p53 in human glioblastoma

Authors

Leopoldo A. García-Montaño, The Brain Tumor Translational Laboratory, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico
Yamhilette Licon Munoz, The Brain Tumor Translational Laboratory, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico
Frank Martinez, The Brain Tumor Translational Laboratory, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico
Kandee Gallegos, New Mexico Highlands University, Las Vegas, New Mexico
Huining Kang, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico
Sara G.M Piccirillo, The Brain Tumor Translational Laboratory, Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico

Document Type

Poster

Publication Date

3-22-2024

Abstract

Glioblastoma is the most common malignant brain tumor in adults. In contrast to several cancers, where the tumor suppressor gene TP53 is altered, most glioblastoma patients retain a non-mutant TP53 gene. However, the survival of these patients is similar to that of mutant patients, suggesting that p53 is nonfunctional. To test this hypothesis, we analyzed data from The Cancer Genome Atlas, identified potential regulators of p53, and we will test their function in patient-derived cells.

Recommended Citation

García-Montaño, Leopoldo A.; Yamhilette Licon Munoz; Frank Martinez; Kandee Gallegos; Huining Kang; and Sara G.M Piccirillo. "Dissecting the functional impairment of wild-type p53 in human glioblastoma." (2024). https://digitalrepository.unm.edu/hsc-bbhrd/184