ASCL1 regulates astrocyte and oligodendrocyte cell fate, proliferation, and migration in the dorsal cortex

Authors

Luis E. Paez-Beltran, Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico
Bianca L. Myers, Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico
Milindu Liyanapathirana, Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico
Haojie Chen, Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico
Estrella Villicana, Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico
Tou Yia Vue, Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico; University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico

Document Type

Poster

Publication Date

3-22-2024

Abstract

Crucial questions in developmental neuroscience are how a common progenitor gives rise to different cell types and how development changes over time. This study explores both questions by examining how ASCL1 regulates the cell fate, migration, and proliferation of glial progenitors and how they give rise to different progeny at different stages. Understanding the mechanisms of neurodevelopment not only increases our understanding of fundamental biology but allows us to comprehend pathologies that share similar mechanisms.

Recommended Citation

Paez-Beltran, Luis E.; Bianca L. Myers; Milindu Liyanapathirana; Haojie Chen; Estrella Villicana; and Tou Yia Vue. "ASCL1 regulates astrocyte and oligodendrocyte cell fate, proliferation, and migration in the dorsal cortex." (2024). https://digitalrepository.unm.edu/hsc-bbhrd/183