Document Type
Poster
Publication Date
3-22-2024
Abstract
Hyperhomocysteinemia, or elevated levels of blood homocysteine, is a metabolic condition caused by dietary deficiency of folate, vitamin B12, and vitamin B6 and has been implicated in neurological disorders including ischemic stroke and dementia. We show that following ischemic stroke, hyperhomocysteinemia exacerbates brain damage by triggering a neuro-inflammatory response via a unique intracellular pathway involving GluN2A-NMDA receptors. As such, inhibiting this pathway could yield potential drug targets to mitigate brain damage in hyperhomocysteinemic stroke patients.
Recommended Citation
Seelig, Sarah; Prabu Paramasivam; Surojit Paul; and Ranjana Poddar. "Glun2A-NMDAR Mediated Increased Neuronal Prostaglandin E2 Release and Microglial Activation Exacerbates Ischemic Brain Injury Under Hyperhomocysteinemic." (2024). https://digitalrepository.unm.edu/hsc-bbhrd/178
