Selectively targeting S1PR1 restores BBB integrity and attenuates SVD-related neuropathological progression in a rat model of chronic hypoxic hypoperfusion

Authors

• Jeffrey Thompson, Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, 87131, United States; Memory and Aging Center, University of New Mexico School of Medicine, Albuquerque, NM, 87131, United States
• Yirong Yang, College of Pharmacy, University of New Mexico School of Medicine, Albuquerque, NM, 87131, United States
• Kelsey Duval
• Karen SantaCruz, Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, 87131, United States
• Michael Griego, Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, 87131, United States
• Haojie Chen, Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, 87131, United States
• Haoran Deng, Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, 87131, United States
• Carlos Perez, Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, 87131, United States
• Sean Maez, Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, 87131, United States
• Sasha Hobson, Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, 87131, United States; Memory and Aging Center, University of New Mexico School of Medicine, Albuquerque, NM, 87131, United States
• Theodore Li, Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, 87131, United States
• Halima Akter, Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, 87131, United States
• Michel Torbey, Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, 87131, United States
• Yi Yang, Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, 87131, United States

Document Type

Poster

Publication Date

3-22-2024

Abstract

Cerebral Small Vessel Disease (SVD) contributes to 50% of human dementias world-wide. Human studies indicate a causative role of microvascular endothelial dysfunction, including blood-brain barrier (BBB) dysfunction in SVD. A potential link between BBB dysfunction and tissue hypoxic hypoperfusion underlying the essentials of SVD has been postulated; however, the mechanism(s) remains an open question. This study proposes the reversal of BBB disruption through pharmacological intervention of S1PR1 signaling as a novel therapeutic target for SVD.

Funding: This study is supported by a NIH/NINDS grant (1RF1NS110724) and a UNM MOS RAC grant to Dr. Yi Yang.

Recommended Citation

Thompson, Jeffrey; Yirong Yang; Kelsey Duval; Karen SantaCruz; Michael Griego; Haojie Chen; Haoran Deng; Carlos Perez; Sean Maez; Sasha Hobson; Theodore Li; Halima Akter; Michel Torbey; and Yi Yang. "Selectively targeting S1PR1 restores BBB integrity and attenuates SVD-related neuropathological progression in a rat model of chronic hypoxic hypoperfusion." (2024). https://digitalrepository.unm.edu/hsc-bbhrd/177