Single nucleus transcriptomics reveals cell type-specific heterogeneity on the effects of gestational ozone exposure within the brain

Authors

Sumira Phatak, University of New Mexico, Department of Pharmaceutical Sciences
Kathryn Brayer, University of New Mexico, Department of Molecular Medicine
Russell Hunter, University of New Mexico, Department of Pharmaceutical Sciences
David Scieszka, University of New Mexico, Department of Pharmaceutical Sciences
Andrea Pasmay, University of New Mexico, Department of Neurosciences
Selita Lucas, University of New Mexico, Department of Pharmaceutical Sciences
Jamie Padilla, University of New Mexico, Department of Molecular Medicine
Matthew Campen, University of New Mexico, Department of Pharmaceutical Sciences
Shahani Noor, University of New Mexico, Department of Neurosciences

Document Type

Poster

Publication Date

3-22-2024

Abstract

Air pollution, particularly ozone, is a major global health concern that impacts respiratory health and has been linked to pregnancy-related complications. Our study exposed mice to ozone during early pregnancy, revealing significant changes within the cells of the brain. Combined ozone exposure and pregnancy affected pathways associated with neurodegenerative diseases, potentially influencing long-term maternal and offspring health. These findings highlight the importance of addressing air pollution's impact on both respiratory and neurological health during pregnancy.

Recommended Citation

Phatak, Sumira; Kathryn Brayer; Russell Hunter; David Scieszka; Andrea Pasmay; Selita Lucas; Jamie Padilla; Matthew Campen; and Shahani Noor. "Single nucleus transcriptomics reveals cell type-specific heterogeneity on the effects of gestational ozone exposure within the brain." (2024). https://digitalrepository.unm.edu/hsc-bbhrd/150