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Research indicates prenatal alcohol exposure (PAE) increases the risk of heightened touch sensitivity after minor nerve injury due to inflammation. We explored how non-coding circular RNAs (circRNAs) may influence this. Using rat models, we found 18 circRNAs significantly altered by PAE. These circRNAs regulate genes related to immune responses, including the NF-κB pathway, crucial in inflammation. One circRNA, circVopp1, potentially affects NF-κB activity. Further study may identify circVopp1 as a biomarker for fetal alcohol spectrum disorder and a target for treatment.

FUNDING: This work was supported by T34 GM145428, R01 AA025967, R21 AA023051, T32-AA014127, P50 AA022534 and R01AA029694



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