CircVopp1: A Potentially New Regulator of Long-Term Immune Dysfunction in the Peripheral and Central Nervous System Arising from Prenatal Alcohol Exposure

Authors

• Ariana N. Pritha, University of New Mexico, School of Medicine, Department of Neurosciences, Albuquerque, New Mexico, USA
• Andrea A. Pasmay, University of New Mexico, School of Medicine, Department of Neurosciences, Albuquerque, New Mexico, USA
• Michaela Dell'Orco, University of New Mexico, School of Medicine, Department of Neurosciences, Albuquerque, New Mexico, USA
• Joshua J. Sanchez, University of New Mexico, School of Medicine, Department of Neurosciences, Albuquerque, New Mexico, USA
• Jacob E. Sanchez, University of New Mexico, School of Medicine, Department of Neurosciences, Albuquerque, New Mexico, USA
• Suzy Davies, University of New Mexico, School of Medicine, Department of Neurosciences, Albuquerque, New Mexico, USA
• Daniel D. Savage, University of New Mexico, School of Medicine, Department of Neurosciences, Albuquerque, New Mexico, USA
• Nikolaos Mellios, University of New Mexico, School of Medicine, Department of Neurosciences, Albuquerque, New Mexico, USA
• Erin D. Milligan, University of New Mexico, School of Medicine, Department of Neurosciences, Albuquerque, New Mexico, USA
• Shahani Noor, University of New Mexico, School of Medicine, Department of Neurosciences, Albuquerque, New Mexico, USA

Document Type

Poster

Publication Date

3-22-2024

Abstract

Research indicates prenatal alcohol exposure (PAE) increases the risk of heightened touch sensitivity after minor nerve injury due to inflammation. We explored how non-coding circular RNAs (circRNAs) may influence this. Using rat models, we found 18 circRNAs significantly altered by PAE. These circRNAs regulate genes related to immune responses, including the NF-κB pathway, crucial in inflammation. One circRNA, circVopp1, potentially affects NF-κB activity. Further study may identify circVopp1 as a biomarker for fetal alcohol spectrum disorder and a target for treatment.

FUNDING: This work was supported by T34 GM145428, R01 AA025967, R21 AA023051, T32-AA014127, P50 AA022534 and R01AA029694

Recommended Citation

Pritha, Ariana N.; Andrea A. Pasmay; Michaela Dell'Orco; Joshua J. Sanchez; Jacob E. Sanchez; Suzy Davies; Daniel D. Savage; Nikolaos Mellios; Erin D. Milligan; and Shahani Noor. "CircVopp1: A Potentially New Regulator of Long-Term Immune Dysfunction in the Peripheral and Central Nervous System Arising from Prenatal Alcohol Exposure." (2024). https://digitalrepository.unm.edu/hsc-bbhrd/149