Authors
Ariana N. Pritha, University of New Mexico, School of Medicine, Department of Neurosciences, Albuquerque, New Mexico, USA
Andrea A. Pasmay, University of New Mexico, School of Medicine, Department of Neurosciences, Albuquerque, New Mexico, USA
Michaela Dell'Orco, University of New Mexico, School of Medicine, Department of Neurosciences, Albuquerque, New Mexico, USA
Joshua J. Sanchez, University of New Mexico, School of Medicine, Department of Neurosciences, Albuquerque, New Mexico, USA
Jacob E. Sanchez, University of New Mexico, School of Medicine, Department of Neurosciences, Albuquerque, New Mexico, USA
Suzy Davies, University of New Mexico, School of Medicine, Department of Neurosciences, Albuquerque, New Mexico, USA
Daniel D. Savage, University of New Mexico, School of Medicine, Department of Neurosciences, Albuquerque, New Mexico, USA
Nikolaos Mellios, University of New Mexico, School of Medicine, Department of Neurosciences, Albuquerque, New Mexico, USA
Erin D. Milligan, University of New Mexico, School of Medicine, Department of Neurosciences, Albuquerque, New Mexico, USA
Shahani Noor, University of New Mexico, School of Medicine, Department of Neurosciences, Albuquerque, New Mexico, USA
Publication Date
3-22-2024
Abstract
Research indicates prenatal alcohol exposure (PAE) increases the risk of heightened touch sensitivity after minor nerve injury due to inflammation. We explored how non-coding circular RNAs (circRNAs) may influence this. Using rat models, we found 18 circRNAs significantly altered by PAE. These circRNAs regulate genes related to immune responses, including the NF-κB pathway, crucial in inflammation. One circRNA, circVopp1, potentially affects NF-κB activity. Further study may identify circVopp1 as a biomarker for fetal alcohol spectrum disorder and a target for treatment.
FUNDING: This work was supported by T34 GM145428, R01 AA025967, R21 AA023051, T32-AA014127, P50 AA022534 and R01AA029694
Recommended Citation
Pritha, Ariana N.; Andrea A. Pasmay; Michaela Dell'Orco; Joshua J. Sanchez; Jacob E. Sanchez; Suzy Davies; Daniel D. Savage; Nikolaos Mellios; Erin D. Milligan; and Shahani Noor.
"CircVopp1: A Potentially New Regulator of Long-Term Immune Dysfunction in the Peripheral and Central Nervous System Arising from Prenatal Alcohol Exposure."
(2024).
https://digitalrepository.unm.edu/hsc-bbhrd/149
