The Synthesis Of 5- And 8-Dialhylamino-Alkylaminopyrido [2,3-D] Pyridazines As Potential Antimalarial Agents.

Author

William M. Rich

Publication Date

5-29-1968

Abstract

The appearance of strains of malaria resistant to most of the synthetic antimalarial agents has prompted the investigation of new compounds for antimalarial activity. The structural similarities of the nucleus of pyrido [2,3-d] pyridazine to pteridine as well as to the known quinoline antimalarials suggested the possibility of development of potential chemotherapeutic agents based on the ring system.

A series of 5,8 substituted pyrido [2,3-d] pyridazines were prepared in which one substituent was a dialkylaminoalkylamino group and the other substituent either a chloro, ethoxy, or hydroxy group. Ultraviolet, infrared, and nuclear magnetic resonance spectra were reported for all compounds. Structures were assigned on the basis of their nuclear magnetic resonance spectra. The results of the evaluation of some of these compounds in a rodent antimalarial test system were also reported.

Language

English

Document Type

Thesis

Degree Name

Chemistry

Level of Degree

Masters

Department Name

Department of Chemistry and Chemical Biology

First Committee Member (Chair)

Raymond N. Castle

Second Committee Member

Milton Kahn

Third Committee Member

Guido Herman Daub

Recommended Citation

Rich, William M.. "The Synthesis Of 5- And 8-Dialhylamino-Alkylaminopyrido [2,3-D] Pyridazines As Potential Antimalarial Agents.." (1968). https://digitalrepository.unm.edu/chem_etds/207