Biomedical Sciences ETDs
Publication Date
Fall 12-15-2024
Abstract
Estrogens regulate numerous physiological and pathological processes, including broad effects in wound healing. The effects of estrogens are mediated through estrogen receptors (ERs), which include the classical nuclear ERs (ERα and ERβ), which traditionally regulate gene expression, and the 7-transmembrane G protein-coupled estrogen receptor (GPER), which predominately mediates rapid “nongenomic” signaling. Estrogens can regulate epidermal function and regeneration, inflammation, and other functions that are vital to wound healing. We report that GPER is critical in wound healing, facilitating effects that are both dependent and independent of sex. GPER-deficiency is linked with an increase in skin necrosis, decrease in flap perfusion and changed vessel morphology. Together, these findings contribute to understanding GPER signaling in wound healing and suggest possible therapeutic opportunities by targeting GPER.
Keywords
Estrogen, Flap, GPER, Revascularization, Skin, Wound Healing
Document Type
Dissertation
Language
English
Degree Name
Biomedical Sciences
Level of Degree
Doctoral
Department Name
Biomedical Sciences Graduate Program
First Committee Member (Chair)
Judy Cannon, PhD
Second Committee Member
Eric Prossnitz, PhD
Third Committee Member
Meilian Liu, PhD
Fourth Committee Member
Rama Gullapalli, MD, PhD
Recommended Citation
KO, RANDY F.. "THE ROLE OF THE G PROTEIN-COUPLED ESTROGEN RECEPTOR IN WOUND HEALING." (2024). https://digitalrepository.unm.edu/biom_etds/268
