Biomedical Sciences ETDs

Publication Date

Spring 4-14-2022


Prenatal alcohol exposure (PAE) can result in fetal alcohol spectrum disorders (FASD) causing developmental disabilities and neurocognitive deficits. The effects of PAE on neuronal-specific alterations during brain development have been studied extensively but the contribution of the brain vascular system is limited. Recent studies have determined that there are alterations to the cortical microvasculature during PAE, posing new questions about the role of the vasculature and the development of PAE-mediated neurocognitive deficits. Even less studied are the molecular mechanisms that contribute to changes in the vasculature during PAE. As microRNAs (miRNAs) are master post-transcriptional regulators capable of regulating many mRNA transcripts and cellular pathways, they are of great interest to study and target during disease. The central


Prenatal alcohol exposure, MicroRNAs, microvasculature, endothelial cells

Document Type


Degree Name

Biomedical Sciences

Level of Degree


Department Name

Biomedical Sciences Graduate Program

First Committee Member (Chair)

Amy Gardiner

Second Committee Member

Lee Anna Cunningham

Third Committee Member

Jay Naik

Fourth Committee Member

Nora Perrone-Bizzozero

Available for download on Tuesday, May 14, 2024