Biomedical Sciences ETDs
Publication Date
Spring 4-14-2022
Abstract
Prenatal alcohol exposure (PAE) can result in fetal alcohol spectrum disorders (FASD) causing developmental disabilities and neurocognitive deficits. The effects of PAE on neuronal-specific alterations during brain development have been studied extensively but the contribution of the brain vascular system is limited. Recent studies have determined that there are alterations to the cortical microvasculature during PAE, posing new questions about the role of the vasculature and the development of PAE-mediated neurocognitive deficits. Even less studied are the molecular mechanisms that contribute to changes in the vasculature during PAE. As microRNAs (miRNAs) are master post-transcriptional regulators capable of regulating many mRNA transcripts and cellular pathways, they are of great interest to study and target during disease. The central
Keywords
Prenatal alcohol exposure, MicroRNAs, microvasculature, endothelial cells
Document Type
Dissertation
Degree Name
Biomedical Sciences
Level of Degree
Doctoral
Department Name
Biomedical Sciences Graduate Program
First Committee Member (Chair)
Amy Gardiner
Second Committee Member
Lee Anna Cunningham
Third Committee Member
Jay Naik
Fourth Committee Member
Nora Perrone-Bizzozero
Recommended Citation
Perales, Gabriela. "PRENATAL ALCOHOL EXPOSURE ALTERS THE EXPRESSION OF MIR-150-5P AND ITS VASCULAR TARGETS IN BRAIN MICROVASCULAR ENDOTHELIAL CELLS AND DISRUPTS THE STRUCTURE AND INTEGRITY OF THE DEVELOPING BRAIN VASCULATURE." (2022). https://digitalrepository.unm.edu/biom_etds/226
