Immunologic Enhancement of Murine Sarcoma I Tumor System

Author

Fung-Win Shen

Publication Date

1-14-1971

Abstract

The purpose of this project was to study the mechanism of imnunologic enhancement in the mouse a t the cellular level. The Sarcoma I (Sal, H-2^a) murine tumor system was employed as the model for this study. Sal, indigenous to the A/J (H-2^a) strain of mouse, grows progressively in its syngeneic host but is rejected by non-H-2a mice. However, the SaI tumor can be induced to grow progressively in C57BL/KsJ (Ks, H-2d) mice by passive administration of Ks anti-Sal serum at the time of Sal tumor implantation. This phenomenon is termed immunologic enhancement. Hereafter, mice pretreated with anti-Sa l antibody will be referred to as "conditioned" mice.

Language

English

Document Type

Dissertation

Degree Name

Biology

Level of Degree

Doctoral

Department Name

UNM Biology Department

First Committee Member (Chair)

Paul H. Silverman

Second Committee Member

Sei Tokuda

Third Committee Member

Carl E. Cords Jr.

Recommended Citation

Shen, Fung-Win. "Immunologic Enhancement of Murine Sarcoma I Tumor System." (1971). https://digitalrepository.unm.edu/biol_etds/330