Laurin-Sandrow syndrome (LSS) is a rare condition with only a few published cases in studies. This syndrome, originally described by Laurin in 1964 and again by Sandrow in 1970, can involve digit duplication with mirror hand and foot deformity, ulnar and tibial dimelia, and abnormalities of the knee, ankle, and nasal passages. A 7-month-old male infant presented to our clinic with limited function of his hands and feet due to multiple abnormalities. Results of clinical and radiographic examinations were suggestive of LSS, confirmed by a geneticist. Amputations through the knees, reconstructive pollicization of the right hand, and surgical removal of supernumerary digits on both hands led to successful treatment at 13 months of age, with promising findings at 2-year follow-up. Laurin- Sandrow syndrome may be treated successfully using orthopaedic-based techniques. Amputation can be considered depending on the noted severity of LSS.

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