Document Type

Article

Publication Date

7-30-2008

Abstract

Background: Chronic endometritis is a histopathologic diagnosis characterized by endometrial inflammation rich in plasma cells. Through examination of this disease, we hope to further elucidate the meaning of its diagnosis and whether or not it should be more carefully considered when examining specimens. Methods: A retrospective chart and slide review was conducted that focused on the collection of clinical data and the examination and description of previous tissue samples from endometrial biopsies. A total of 94 chronic endometritis cases and 99 controls were identified. All statistical analyses were conducted using SAS version 9.1. Results: Women with chronic endometritis were more likely to be within 41-50 year of age (39/95, 41.1%), with 65.3% of cases in the 31-40 and 41-50 age categories (23/95, 39/95). They were also more likely to be perimenopausal (42/92, P-value 0.0015) and multiparous (79.1%, P-value 0.1358). Additionally, hormone use was found to be significantly associated with endometritis (P-value 0.0299). No specific symptoms were found to correlate with chronic endometritis. Our study confirmed that the presence of lymphocytes (P-value <0.0001), neutrophils (P-value 0.0029), and macrophages (P-value 0.0048) are associated with endometritis along with epithelial change/metaplasia (P-value 0.0595). Discussion: Our study has helped to better understand the demographics of endometritis and its clinical presentation; but as always, more studies are needed to further elucidate the implications of this disease for women.

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