Psychosocial and Cultural Determinants of Interest and Uptake of Skin Cancer Genetic Testing in Diverse Primary Care

Authors

Jennifer L. Hay, Memorial Sloan Kettering Cancer Center, New York, NY
Krirsten Meyer White, University of New Mexico, Albuquerque, NM
Andrew Sussman, University of New Mexico, Albuquerque, NM
Kim Kaphingst, Huntsman Cancer Center, University of Utah, Salt Lake City, UT
Dolores Guest, University of New Mexico, Albuquerque, NM
Elizabeth Zielaskowski, Memorial Sloan Kettering Cancer Center, New York, NY
Yvonne T. Dailey, University of New Mexico, Albuquerque, NM
Erika Roberts, University of New Mexico, Albuquerque, NM
Matthew R. Schwartz, University of New Mexico, Albuquerque, NM
Kate Zielaskowski, Memorial Sloan Kettering Cancer Center, New York, NY
Yuelin Li, Memorial Sloan Kettering Cancer Center, New York, NY
David Buller, Klein Buendel, Inc., Golden, CO
Keith Hunley, University of New Mexico, Albuquerque, NM
Marianne Berwick, University of New Mexico, Albuquerque, NM

Document Type

Article

Publication Date

8-22-2019

Abstract

Background: Translational research in genomics has limited reach and requires efforts to broaden access and utility in diverse populations. Skin cancer is common and rates are rising, including among Hispanics. Germline variants in the melanocortin-1 receptor (MC1R) gene are common in the population and confer moderate risk for melanoma and basal cell cancers across skin types. Feedback about MC1R risk status may promote skin cancer risk awareness and risk reduction. Aims: We examined the level of interest in pursuing MC1R testing, and patterns of interest across skin cancer perceived threat and control attitudes, cultural beliefs (family influence on health, health system distrust, cancer fatalism, skin cancer misconceptions), and health literacy. Methods: We used a study website to inform primary care patients in Albuquerque, NM about the benefits and drawbacks of MC1R testing. Website logon, request of a saliva test kit, and return of the test kit (yes vs. no) were primary assessments of study interest and uptake. Results: Of 499 participants provided with a test offer, 33% requested and returned the test. Lower family influence on participants’ health was an important factor both overall and within ethnicity subgroups, and may indicate that primary care patients interested in skin cancer genetic testing see themselves as proactive health seekers, independent from family encouragement. Lower self-efficacy for skin cancer prevention was also an important characteristic of those who tested. Conclusion: As evidence for common genetic markers for skin cancer accumulates, these findings suggest characteristics of those most likely to pursue genetic testing for skin cancer risk.

Recommended Citation

Hay J, L, Meyer White K, Sussman A, Kaphingst K, Guest D, Schofield E, Dailey Y, T, Robers E, Schwartz M, R, Zielaskowski K, Li Y, Buller D, Hunley K, Berwick M: Psychosocial and Cultural Determinants of Interest and Uptake of Skin Cancer Genetic Testing in Diverse Primary Care. Public Health Genomics 2019;22:58-68. doi: 10.1159/000501985