Establishing Time Course of Testosterone Using Saliva After a Sublingual Administration: A Pilot Study
Start Date
8-11-2017 8:30 AM
End Date
8-11-2017 12:30 PM
Abstract
Sublingual administration of 0.05 mg of testosterone has been found to be a safe and effective method to induce higher testosterone levels in females. In previous studies, blood serum levels have been used to establish the time course of testosterone. Although measuring blood serum is accurate, it is often invasive for the participant. Measuring testosterone using saliva, on the other hand, is less invasive for the participants and does not require the presence of a phlebotomist. A double-blind pilot study was conducted to examine whether a sublingual administration of testosterone using saliva samples to establish testosterone level were similar to previously reported studies using blood serum. Because it is unknown whether contaminants from the sublingual administration will alter the accuracy of the saliva measurements, participants were divided into a Non-Rinse and Rinse condition. The sublingual administration method has not been validated in men, however, they were included in this study to test whether men were similarly affected as women. Finally, behavioral measurements of aggression, risk taking behaviors, and empathy were used to establish the behavioral changes due to testosterone induction. The results from this study will be discussed along with future directions.
Establishing Time Course of Testosterone Using Saliva After a Sublingual Administration: A Pilot Study
Sublingual administration of 0.05 mg of testosterone has been found to be a safe and effective method to induce higher testosterone levels in females. In previous studies, blood serum levels have been used to establish the time course of testosterone. Although measuring blood serum is accurate, it is often invasive for the participant. Measuring testosterone using saliva, on the other hand, is less invasive for the participants and does not require the presence of a phlebotomist. A double-blind pilot study was conducted to examine whether a sublingual administration of testosterone using saliva samples to establish testosterone level were similar to previously reported studies using blood serum. Because it is unknown whether contaminants from the sublingual administration will alter the accuracy of the saliva measurements, participants were divided into a Non-Rinse and Rinse condition. The sublingual administration method has not been validated in men, however, they were included in this study to test whether men were similarly affected as women. Finally, behavioral measurements of aggression, risk taking behaviors, and empathy were used to establish the behavioral changes due to testosterone induction. The results from this study will be discussed along with future directions.
