Psychology ETDs

Publication Date

Spring 5-16-2026

Abstract

The Addictions Neuroclinical Assessment (ANA) is a multimodal clinical assessment framework designed to capture the heterogeneity of addictive disorders and inform personalized treatment. The ANA is grounded in three neurofunctional domains aligned with the Koob and LeMoal addiction cycle stages: incentive salience (IS; binge/intoxication), negative emotionality (NE; withdrawal/negative affect), and executive function (EF; preoccupation/anticipation). In addition to these primary domains, the ANA also proposes ancillary assessment domains thought to be related to these neurofunctional domains. However, the ANA developers do not provide a rationale for including these ancillary measures in the framework nor hypothesize about their relevance to the ANA domains; this leaves questions about how these ancillary variables are related to the ANA domains and how they may be implicated in the addiction cycle. This study used structural equation modeling (SEM) to examine cross-sectional associations between ANA domains and socioecological factors (socioeconomic status, stress, activity level, nutrition) in two independent samples. Despite higher dysfunction levels in the ANA domains in the treatment-seeking sample, both samples showed comparable associations between ANA domains and socioecological factors, suggesting that these factors remain similarly associated across a spectrum of severity.

Degree Name

Psychology

Level of Degree

Masters

Department Name

Psychology

First Committee Member (Chair)

Cassandra Boness

Second Committee Member

Katie Witkiewitz

Third Committee Member

Yu-Yu Hsiao

Language

English

Keywords

Addictions Neuroclinical Assessment, addiction cycle, socioecological factors, alcohol use, alcohol use disorder

Document Type

Thesis

Download

Included in

Psychology Commons

Share

COinS