Metabolic Reprogramming and Cell Adhesion in Acute Leukemia Adaptation to the CNS Niche

Authors

Nitesh D. Sharma, Department of Pediatrics, Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, NM, United States; Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM, United States
Esra'a Keewan, Department of Pediatrics, Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, NM, United States; Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM, United States
Ksenia Matlawska-Wasowska, Department of Pediatrics, Division of Hematology-Oncology, University of New Mexico Health Sciences Center, Albuquerque, NM, United States; Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM, United States

Document Type

Article

Publication Date

1-1-2021

Abstract

Involvement of the Central Nervous System (CNS) in acute leukemia confers poor prognosis and lower overall survival. Existing CNS-directed therapies are associated with a significant risk of short- or long-term toxicities. Leukemic cells can metabolically adapt and survive in the microenvironment of the CNS. The supporting role of the CNS microenvironment in leukemia progression and dissemination has not received sufficient attention. Understanding the mechanism by which leukemic cells survive in the nutrient-poor and oxygen-deprived CNS microenvironment will lead to the development of more specific and less toxic therapies. Here, we review the current literature regarding the roles of metabolic reprogramming in leukemic cell adhesion and survival in the CNS.

Publication Title

Front Cell Dev Biol

ISSN

2296-634X

Volume

9

First Page

767510

Last Page

767510

DOI

10.3389/fcell.2021.767510

Recommended Citation

Sharma ND, Keewan E, Matlawska-Wasowska K. Metabolic Reprogramming and Cell Adhesion in Acute Leukemia Adaptation to the CNS Niche. Front Cell Dev Biol. 2021 Dec 10;9:767510. doi: 10.3389/fcell.2021.767510. PMID: 34957100; PMCID: PMC8703109.