Systemic sclerosis manifestations and clinical outcomes in Hispanics/Latinos of the American Southwest
Objective: Certain Hispanic/Latino (Hispanic) populations have been reported to have higher rates and severity of systemic sclerosis; however, little is known of systemic sclerosis in the American Southwest. This study compared manifestations of systemic sclerosis in Hispanics with non-Hispanics of New Mexico.
Methods: This cross-sectional longitudinal study included 109 systemic sclerosis patients followed over a mean of 12.6 ± 8.9 years. Subjects were repetitively evaluated including physical examination, echocardiography, chest imaging, and serologic testing and observed for complications. Disease characteristics and long-term outcomes were statistically compared between self-identified Hispanic and non-Hispanic subjects.
Results: A total of 73 (67%) systemic sclerosis subjects were Hispanic and 36 (33%) were non-Hispanic. The cohorts were similar in mean age, age of systemic sclerosis onset, limited versus diffuse cutaneous systemic sclerosis, telangiectases, gastroesophageal reflux disease, Raynaud's phenomenon, autoantibody profile, interstitial lung disease, pulmonary hypertension, scleroderma renal crisis, mortality, and comorbid malignancy (all
Conclusion: Systemic sclerosis phenotype, autoantibodies, complications, outcomes, malignancy rates, and mortality are generally similar between Hispanics and non-Hispanics with systemic sclerosis in the American Southwest. However, age-adjusted comorbid malignancy and mortality rates are significantly increased in both groups.
J Scleroderma Relat Disord
Nunez SE, Ariza-Hutchinson A, Fields RA, Vondenberg JA, Patel RA, Emil NS, Muruganandam M, Gibb JI, Poole JL, Sibbitt WL Jr. Systemic sclerosis manifestations and clinical outcomes in Hispanics/Latinos of the American Southwest. J Scleroderma Relat Disord. 2022 Jun;7(2):135-143. doi: 10.1177/23971983221086214. Epub 2022 Apr 10. PMID: 35585952; PMCID: PMC9109509.