Systemic sclerosis manifestations and clinical outcomes in Hispanics/Latinos of the American Southwest

Authors

Sharon E. Nunez, Department of Internal Medicine, Division of Rheumatology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
Angie Ariza-Hutchinson, Department of Internal Medicine, Division of Rheumatology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
Roderick A. Fields, Department of Internal Medicine, Division of Rheumatology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
Jaime A. Vondenberg, Department of Medicine, Rheumatology/Immunology, Cleveland Clinic, Cleveland, OH, USA
Rosemina A. Patel, Department of Internal Medicine, Division of Rheumatology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
N Suzanne Emil, Department of Internal Medicine, Division of Rheumatology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
Maheswari Muruganandam, Department of Internal Medicine, Division of Rheumatology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
James I. Gibb, Department of Internal Medicine, Division of Rheumatology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
Janet L. Poole, Department of Internal Medicine, Division of Rheumatology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
Wilmer L. Sibbitt, Department of Internal Medicine, Division of Rheumatology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA

Document Type

Article

Publication Date

6-1-2022

Abstract

Objective: Certain Hispanic/Latino (Hispanic) populations have been reported to have higher rates and severity of systemic sclerosis; however, little is known of systemic sclerosis in the American Southwest. This study compared manifestations of systemic sclerosis in Hispanics with non-Hispanics of New Mexico.

Methods: This cross-sectional longitudinal study included 109 systemic sclerosis patients followed over a mean of 12.6 ± 8.9 years. Subjects were repetitively evaluated including physical examination, echocardiography, chest imaging, and serologic testing and observed for complications. Disease characteristics and long-term outcomes were statistically compared between self-identified Hispanic and non-Hispanic subjects.

Results: A total of 73 (67%) systemic sclerosis subjects were Hispanic and 36 (33%) were non-Hispanic. The cohorts were similar in mean age, age of systemic sclerosis onset, limited versus diffuse cutaneous systemic sclerosis, telangiectases, gastroesophageal reflux disease, Raynaud's phenomenon, autoantibody profile, interstitial lung disease, pulmonary hypertension, scleroderma renal crisis, mortality, and comorbid malignancy (all

Conclusion: Systemic sclerosis phenotype, autoantibodies, complications, outcomes, malignancy rates, and mortality are generally similar between Hispanics and non-Hispanics with systemic sclerosis in the American Southwest. However, age-adjusted comorbid malignancy and mortality rates are significantly increased in both groups.

Publication Title

J Scleroderma Relat Disord

ISSN

2397-1991

Volume

7

Issue

2

First Page

135

Last Page

143

DOI

10.1177/23971983221086214

Recommended Citation

Nunez SE, Ariza-Hutchinson A, Fields RA, Vondenberg JA, Patel RA, Emil NS, Muruganandam M, Gibb JI, Poole JL, Sibbitt WL Jr. Systemic sclerosis manifestations and clinical outcomes in Hispanics/Latinos of the American Southwest. J Scleroderma Relat Disord. 2022 Jun;7(2):135-143. doi: 10.1177/23971983221086214. Epub 2022 Apr 10. PMID: 35585952; PMCID: PMC9109509.

Comments

• PMCID: PMC9109509 (available on 2023-06-01)