Overlapping roles of NADPH Oxidase 4 (Nox4) for diabetic and gadolinium-based contrast agent-induced systemic fibrosis-Animal Equivalent Dosing of Gadolinium-based contrast agents Supplementary Figure 1

Creators

Francesca Bruno, Eboli Hospital “Maria SS Addolorata,” UOC of Nephrology and Dialysis, Eboli, Italy
Joshua DeAguero, Kidney Institute of New Mexico, University of New Mexico Health Science Center, New Mexico Veterans Administration Health Care System
Catherine Do, Kidney Institute of New Mexico, University of New Mexico Health Science Center, New Mexico Veterans Administration Health Care System
Doug Yoon Lee, University of Texas Health System
Chunyan Tan, University of Texas Health System
G Patricia Escobar, Kidney Institute of New Mexico, University of New Mexico Health Science Center, New Mexico Veterans Administration Health Care System
Brent Wagner, Kidney Institute of New Mexico, University of New Mexico Health Science Center, New Mexico Veterans Administration Health Care System

Description/Summary

This is supplementary material for the forthcoming publication entitled “Overlapping roles of NADPH Oxidase 4 (Nox4) for diabetic and gadolinium-based contrast agent-induced systemic fibrosis”. This supplementary material utilizes a model for gadolinium retention and renal elimination of pharmaceuticals, interspecies allometric scaling to determine animal equivalent dosing, label dosing and published studies of varying and repetitive dosing of gadolinium-based contrast agents used to determine dosing of gadolinium-based contrast agents in our preclinical model. Supplementary Figure 1 demonstrates modeling plasma gadolinium-based contrast agent concentrations based on the Hirano Suzuki equation.

Publication Date

2020

Document Type

Article

File Format

PDF

Recommended Citation

Bruno, Francesca; Joshua DeAguero; Catherine Do; Doug Yoon Lee; Chunyan Tan; G Patricia Escobar; and Brent Wagner. "Overlapping roles of NADPH Oxidase 4 (Nox4) for diabetic and gadolinium-based contrast agent-induced systemic fibrosis-Animal Equivalent Dosing of Gadolinium-based contrast agents Supplementary Figure 1." (2020). https://digitalrepository.unm.edu/kinm/2