Recommendations for Clinical Laboratory Testing for Protein S Deficiency: Communication from the SSC Committee Plasma Coagulation Inhibitors of the ISTH

Authors

Richard A. Marlar, Department of Pathology, TriCore Reference Laboratories, University of New Mexico, Albuquerque, NM, USA
Jana N. Gausman, OU Medicine, Inc, Laboratory, University of Oklahoma Medical Center, Oklahoma City, OK, USA
Hiroko Tsuda, Department of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan
Marian A. Rollins-Raval, Department of Pathology, TriCore Reference Laboratories, University of New Mexico, Albuquerque, NM, USA
Herm Jan M. Brinkman, Department of Molecular and Cellular Hemostasis, Sanquin Research, Amsterdam, The Netherlands

Document Type

Article

Publication Date

1-1-2021

Abstract

Hereditary deficiencies of protein S (PS) increase the risk of venous thrombosis; however, assessing the plasma levels of PS can be difficult because of its complex physiological interactions in plasma, sample-related preanalytical variables, and numerous acquired disease processes. Reliable laboratory assays are essential for accurate evaluation of PS when diagnosing a congenital deficiency based on the plasma phenotype alone. This report presents the current evidence-based recommendations for clinical PS assays as well as when to test for PS abnormalities.

Recommended Citation

Marlar RA, Gausman JN, Tsuda H, Rollins-Raval MA, Brinkman HJM. Recommendations for clinical laboratory testing for protein S deficiency: Communication from the SSC committee plasma coagulation inhibitors of the ISTH. J Thromb Haemost. 2021 Jan;19(1):68-74. doi: 10.1111/jth.15109. PMID: 33405382.