OCT4 Negatively Regulates the Transcriptional Programming of the Early Region 3 Immune Evasion Genes of Human Adenovirus

Document Type

Article

Publication Date

4-25-2025

Abstract

Genomes of viruses are constrained by the virions' nanoscale, and viral nucleotide sequences without function are a luxury. Yet the double-stranded DNA genome of human adenovirus (HAdV) contains large regions without known purpose. Using TRANSFAC and ChIP-Seq analysis, we identified binding of OCT4 (octomer-binding transcription factor 4) to a noncoding region of HAdV-D37 DNA. Manipulation of OCT4 expression impacted viral E3 gene transcription and gp19k protein expression, altering subsequent MHC Class I expression. These effects were specific to OCT4 binding to the adenovirus 5

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