Two Rare Cases of Paratubal Leydig Cell Nodules: Clinical Relevance and Debated Terminology of a Noteworthy Incidentaloma

Authors

• Edgar G. Fischer, Division of Surgical Pathology and Cytopathology, Department of Pathology, University of New Mexico, Albuquerque, New Mexico.

Document Type

Article

Publication Date

1-1-2024

Abstract

Cells with cytologic and immunohistochemical features of Leydig cells are normally present in the ovary and the ovarian hilum, are testosterone-producing, and have been referred to as ovarian hilus cells. Rarely these cells form nests or nodules in extraovarian sites such as the mesovarium or mesosalpinx. Because they are so rare, these nodules can present a diagnostic challenge when first encountered. This report describes 2 such incidental nodules in the mesosalpinx associated with a small paratubal cyst and suggests that the term Leydig cell nodule be preferred over the nonspecific and confusing historical term ovarian hilus cell nest.

Recommended Citation

Fischer EG. Two Rare Cases of Paratubal Leydig Cell Nodules: Clinical Relevance and Debated Terminology of a Noteworthy Incidentaloma. Int J Gynecol Pathol. 2024 Jan 1;43(1):97-101. doi: 10.1097/PGP.0000000000000960. Epub 2023 May 31. PMID: 38081059.