VEXAS Syndrome Unveiled: A Multidimensional Journey From Clinical Presentation to Management

Authors

• Tomas Escobar Gil, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
• Darrell D. Horton, Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
• Oscar F. Borja Montes, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
• Daniel Babu, Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
• Abu Baker Sheikh, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.

Document Type

Article

Publication Date

1-1-2024

Abstract

An 83-year-old man with a history of monoclonal gammopathy of unknown significance, macrocytic anemia, and cytopenias presented with hemorrhagic bullae on his left hand, alongside intermittent fevers and joint pain. Laboratory findings indicated anemia, elevated mean corpuscular volume, thrombocytopenia, leukopenia, and a high C-reactive protein level. A biopsy of the bullae showed neutrophilic dermatosis, and computed tomography scans of the thorax revealed lung opacities and mediastinal lymphadenopathy, suggesting neutrophilic alveolitis. Bone marrow examination found hypercellularity with myeloid and histiocytic hyperplasia, vacuolated precursors, and 3% blasts of an immature myelomonocytic lineage. Genetic testing uncovered a

Recommended Citation

Escobar Gil T, Horton DD, Borja Montes OF, Babu D, Sheikh AB. VEXAS syndrome unveiled: a multidimensional journey from clinical presentation to management. Proc (Bayl Univ Med Cent). 2024 May 15;37(5):858-861. doi: 10.1080/08998280.2024.2352963. PMID: 39165813; PMCID: PMC11332627.