Neuroinflammatory and Metabolomic Temporal Dynamics Following Wood Smoke Inhalation

Authors

David Scieszka, University of New Mexico, College of Pharmacy.
Yan Jin, Florida International University, Center for Translational Sciences.
Shahani Noor, University of New Mexico, Department of Molecular Genetics and Microbiology.
Ed Barr, University of New Mexico, College of Pharmacy.
Marcus Garcia, University of New Mexico, College of Pharmacy.
Jessica Begay, University of New Mexico, College of Pharmacy.
Guy Herbert, University of New Mexico, College of Pharmacy.
Russell P. Hunter, University of New Mexico, College of Pharmacy.
Kiran Bhaskar, University of New Mexico, Department of Molecular Genetics and Microbiology.
Rahul Kumar, University of New Mexico, Department of Pathology.
Rama Gullapalli, University of New Mexico, Department of Pathology.
Alicia Bolt, University of New Mexico, College of Pharmacy.
Mark A. McCormick, University of New Mexico, Department of Biochemistry and Molecular Biology.
Barry Bleske, University of New Mexico, Department of Pharmacy Practice and Administrative Science.
Haiwei Gu, Florida International University, Center for Translational Sciences.
Matthew Campen, University of New Mexico, College of Pharmacy.

Document Type

Article

Publication Date

6-5-2023

Abstract

Smoke from wildland fires has been shown to produce neuroinflammation in preclinical models, characterized by neural infiltrations of neutrophils and monocytes, as well as altered neurovascular endothelial phenotypes. To address the longevity of such outcomes, the present study examined the neuroinflammatory and metabolomic temporal dynamics after inhalation exposures from biomass-derived smoke. 2-month-old female C57BL/6J mice were exposed to wood smoke every other day for two weeks at an average exposure concentration of 0.5mg/m

Recommended Citation

Scieszka D, Jin Y, Noor S, Barr E, Garcia M, Begay J, Herbert G, Hunter RP, Bhaskar K, Kumar R, Gullapalli R, Bolt A, McCormick MA, Bleske B, Gu H, Campen M. Neuroinflammatory and Metabolomic Temporal Dynamics Following Wood Smoke Inhalation. Res Sq [Preprint]. 2023 Jun 5:rs.3.rs-3002040. doi: 10.21203/rs.3.rs-3002040/v1. Update in: J Neuroinflammation. 2023 Aug 22;20(1):192. PMID: 37333410; PMCID: PMC10275049.