Authors
Xuexiang Zhang, Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA
Tae-Hyung Kim, Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pathology, University of New Mexico School of Medicine
Timothy J. Thauland, Division of Immunology, Allergy, and Rheumatology, Department of Pediatrics, University of California, Los Angeles, Los Angeles, CA 90095, USA
Hongjun Li, Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA
Fatemeh Sadat Majedi, Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA
Chau Ly, Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA
Zhen Gu, Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA
Manish J. Butte, Division of Immunology, Allergy, and Rheumatology, Department of Pediatrics, University of California, Los Angeles, Los Angeles, CA 90095, USA
Amy C. Rowat, Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA
Song Li, Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA
Publication Date
2-1-2022
Abstract
Immune cells can sense and respond to biophysical cues — from dynamic forces to spatial features — during their development, activation, differentiation and expansion. These biophysical signals regulate a variety of immune cell functions such as leukocyte extravasation, macrophage polarization, T cell selection and T cell activation. Recent studies have advanced our understanding on immune responses to biophysical cues and the underlying mechanisms of mechanotransduction, which provides rational basis for the design and development of immune-modulatory therapeutics. This review discusses the recent progress in mechanosensing and mechanotransduction of immune cells, particularly monocytes/macrophages and T lymphocytes, and features new biomaterial designs and biomedical devices that translate these findings into biomedical applications.
Recommended Citation
Zhang X, Kim TH, Thauland TJ, Li H, Majedi FS, Ly C, Gu Z, Butte MJ, Rowat AC, Li S. Corrigendum to "Unraveling the mechanobiology of immune cells" [Curr Opin Biotechnol 66 (2020) 236-245]. Curr Opin Biotechnol. 2022 Feb;73:387-388. doi: 10.1016/j.copbio.2021.10.019. Epub 2021 Dec 9. Erratum for: Curr Opin Biotechnol. 2020 Dec;66:236-245. PMID: 34895976; PMCID: PMC8655620.
Comments
The authors regret that a few references were incorrectly cited in Table 1 . Reference [51] under “ECM Stiffness” should be replaced with [49]. [49] should be replaced with [50]. [50] should be replaced with [51]. [23] should be replaced with [20]. [51] under “Microstructure Confinement” should be replaced with [52]. The authors would like to apologise for any inconvenience caused.