Iron Promotes Glycolysis to Drive Colon Tumorigenesis.

Authors

• Zhaoli Liu, Department of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM 87131, USA.
• Luke Villareal, Department of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM 87131, USA.
• Lavanya Goodla, Department of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM 87131, USA.
• Hyeoncheol Kim, Department of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM 87131, USA.
• Daniel M. Falcon, Department of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM 87131, USA.
• Mohammad Haneef, Department of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM 87131, USA.
• David R. Martin, Department of Pathology, University of New Mexico, Albuquerque, NM 87131, USA.
• Li Zhang, Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
• Ho-Joon Lee, Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
• Daniel Kremer, Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
• Costas A. Lyssiotis, Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
• Yatrik M. Shah, Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
• Henry C. Lin, Section of Gastroenterology, Medicine Service, New Mexico VA Health Care System, Albuquerque, NM 87108, USA; Division of Gastroenterology and Hepatology, Department of Medicine, the University of New Mexico, Albuquerque, NM, 87131, USA.
• Hui-Kuan Lin, Department of Pathology, Duke University, Durham, NC 27710, USA.
• Xiang Xue, Department of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM 87131, USA.Follow

Document Type

Article

Publication Date

12-1-2023

Abstract

Colorectal cancer (CRC) is the third most common cancer and is also the third leading cause of cancer-related death in the USA. Understanding the mechanisms of growth and progression of CRC is essential to improve treatment. Macronutrients such as glucose are energy source for a cell. Many tumor cells exhibit increased aerobic glycolysis. Increased tissue micronutrient iron levels in both mice and humans are also associated with increased colon tumorigenesis. However, if iron drives colon carcinogenesis via affecting glucose metabolism is still not clear. Here we found the intracellular glucose levels in tumor colonoids were significantly increased after iron treatment.

Recommended Citation

Liu Z, Villareal L, Goodla L, Kim H, Falcon DM, Haneef M, Martin DR, Zhang L, Lee HJ, Kremer D, Lyssiotis CA, Shah YM, Lin HC, Lin HK, Xue X. Iron promotes glycolysis to drive colon tumorigenesis. Biochim Biophys Acta Mol Basis Dis. 2023 Dec;1869(8):166846. doi: 10.1016/j.bbadis.2023.166846. Epub 2023 Aug 12. PMID: 37579983; PMCID: PMC10530594.