Dysregulation of the PRUNE2/PCA3 Genetic Axis in Human Prostate Cancer: From Experimental Discovery to Validation in Two Independent Patient Cohorts

Authors

• Richard C. Lauer, University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, United States.Division of Hematology/Oncology, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States.
• Marc Barry, Department of Pathology, University of Utah, Salt Lake City, Utah, United States.
• Tracey L. Smith, Rutgers Cancer Institute of New Jersey, Newark, New Jersey, United States.Division of Cancer Biology, Department of Radiation Oncology, Rutgers New Jersey Medical School, Newark, New Jersey, United States.
• Andrew Maltez Thomas, Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
• Jin Wu, University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, United States. Department of Pathology, University of New Mexico, Albuquerque, New Mexico, United States.
• Ruofei Du, Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States.
• Ji-Hyun Lee, Department of Biostatistics, University of Florida, Gainesville, Florida, United States.Division of Quantitative Sciences, University of Florida Health Cancer Center, Gainesville, Florida, United States.
• Arpit Rao, Section of Hematology and Oncology, Department of Medicine, Baylor College of Medicine, Houston, Texas, United States.
• Andrey S. Dobroff, University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, United States. Division of Molecular Medicine, Department of Medicine, Albuquerque, United States.
• Marco A. Arap, Division of Urology, University of São Paulo Medical School, São Paulo, Brazil. Syrian-Lebanese Hospital, São Paulo, Brazil.
• Diana N. Nunes, Laboratory of Medical Genomics, A.C. Camargo Cancer Center, São Paulo, Brazil.
• Israel T. Silva, Laboratory of Bioinformatics and Computational Biology, A.C. Camargo Cancer Center, São Paulo, Brazil.
• Emmanuel Dias-Neto, Laboratory of Medical Genomics, A.C. Camargo Cancer Center, São Paulo, Brazil.
• Isan Chen, MBrace Therapeutics, San Diego, California, United States.
• Dennis J. McCance, University of New Mexico Comprehensive Cancer Center, Albuquerque, New Mexico, United States. Department of Pathology, University of New Mexico, Albuquerque, New Mexico, United States.
• Webster K. Cavenee, Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, California, United States.
• Renata Pasqualini, Rutgers Cancer Institute of New Jersey, Newark, New Jersey, United States. Division of Cancer Biology, Department of Radiation Oncology, Rutgers New Jersey Medical School, Newark, New Jersey, United States.
• Wadih Arap, Rutgers Cancer Institute of New Jersey, Newark, New Jersey, United States. Division of Hematology/Oncology, Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, United States.

Document Type

Article

Publication Date

1-16-2023

Abstract

BACKGROUND: We have previously shown that the long non-coding (lnc)RNA

METHODS: The reciprocal

RESULTS: We consistently observed increased expression of

CONCLUSIONS: We concluded that upregulation of the lncRNA

FUNDING: We received support from the Human Tissue Repository and Tissue Analysis Shared Resource from the Department of Pathology of the University of New Mexico School of Medicine and a pilot award from the University of New Mexico Comprehensive Cancer Center. RP and WA were supported by awards from the Levy-Longenbaugh Donor-Advised Fund and the Prostate Cancer Foundation. EDN reports research fellowship support from the Brazilian National Council for Scientific and Technological Development (CNPq), Brazil, and the Associação Beneficente Alzira Denise Hertzog Silva (ABADHS), Brazil. This work has been funded in part by the NCI Cancer Center Support Grants (CCSG; P30) to the University of New Mexico Comprehensive Cancer Center (CA118100) and the Rutgers Cancer Institute of New Jersey (CA072720).

Recommended Citation

Lauer RC, Barry M, Smith TL, Thomas AM, Wu J, Du R, Lee JH, Rao A, Dobroff AS, Arap MA, Nunes DN, Silva IT, Dias-Neto E, Chen I, McCance DJ, Cavenee WK, Pasqualini R, Arap W. Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: from experimental discovery to validation in two independent patient cohorts. Elife. 2023 Jan 16;12:e81929. doi: 10.7554/eLife.81929. PMID: 36645410; PMCID: PMC9886275.