Biomass Smoke Inhalation Promotes Neuroinflammatory and Metabolomic Temporal Changes in the Hippocampus of Female Mice

Authors

• David Scieszka, Department of Pharmaceutical Sciences College of Pharmacy, University of New Mexico, MSC09 5360; 1, Albuquerque, NM, 87131-0001, USA.
• Yan Jin, Florida International University Center for Translational Sciences, Port St. Lucie, FL, 34987, USA.
• Shahani Noor, Department of Molecular Genetics and Microbiology, Department of Neurology, School of Medicine, University of New Mexico, Albuquerque, NM, 87131, USA.
• Ed Barr, Department of Pharmaceutical Sciences College of Pharmacy, University of New Mexico, MSC09 5360; 1, Albuquerque, NM, 87131-0001, USA.
• Marcus Garcia, Department of Pharmaceutical Sciences College of Pharmacy, University of New Mexico, MSC09 5360; 1, Albuquerque, NM, 87131-0001, USA.
• Jessica Begay, Department of Pharmaceutical Sciences College of Pharmacy, University of New Mexico, MSC09 5360; 1, Albuquerque, NM, 87131-0001, USA.
• Guy Herbert, Department of Pharmaceutical Sciences College of Pharmacy, University of New Mexico, MSC09 5360; 1, Albuquerque, NM, 87131-0001, USA.
• Russell P. Hunter, Department of Pharmaceutical Sciences College of Pharmacy, University of New Mexico, MSC09 5360; 1, Albuquerque, NM, 87131-0001, USA.
• Kiran Bhaskar, Department of Molecular Genetics and Microbiology, Department of Neurology, School of Medicine, University of New Mexico, Albuquerque, NM, 87131, USA.
• Rahul Kumar, Department of Pathology, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, 87131, USA.
• Rama Gullapalli, Department of Pathology, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, 87131, USA.
• Alicia Bolt, Department of Pharmaceutical Sciences College of Pharmacy, University of New Mexico, MSC09 5360; 1, Albuquerque, NM, 87131-0001, USA.
• Mark A. McCormick, Department of Biochemistry and Molecular Biology, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, 87131, USA.
• Barry Bleske, Department of Pharmacy Practice and Administrative Sciences, College of Pharmacy, University of New Mexico, Albuquerque, NM, 87131, USA.
• Haiwei Gu, Florida International University Center for Translational Sciences, Port St. Lucie, FL, 34987, USA.
• Matthew J. Campen, Department of Pharmaceutical Sciences College of Pharmacy, University of New Mexico, MSC09 5360; 1, Albuquerque, NM, 87131-0001, USA.Follow

Document Type

Article

Publication Date

8-22-2023

Abstract

Smoke from wildland fires has been shown to produce neuroinflammation in preclinical models, characterized by neural infiltrations of neutrophils and monocytes, as well as altered neurovascular endothelial phenotypes. To address the longevity of such outcomes, the present study examined the temporal dynamics of neuroinflammation and metabolomics after inhalation exposures from biomass-derived smoke. 2-month-old female C57BL/6 J mice were exposed to wood smoke every other day for 2 weeks at an average exposure concentration of 0.5 mg/m

Recommended Citation

Scieszka D, Jin Y, Noor S, Barr E, Garcia M, Begay J, Herbert G, Hunter RP, Bhaskar K, Kumar R, Gullapalli R, Bolt A, McCormick MA, Bleske B, Gu H, Campen MJ. Biomass smoke inhalation promotes neuroinflammatory and metabolomic temporal changes in the hippocampus of female mice. J Neuroinflammation. 2023 Aug 22;20(1):192. doi: 10.1186/s12974-023-02874-y. PMID: 37608305; PMCID: PMC10464132.