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The neuron-specific gene family (NSG1-3) plays crucial roles in regulating the movement and processing of key proteins within neurons, particularly those involved in Alzheimer's disease and synaptic strength regulation. While NSG1 is known for its importance in proper synaptic function, NSG2's role is less understood. Surprisingly, deleting NSG2 selectively enhanced learning and memory, contrary to predictions. Electrophysiology experiments revealed NSG1 and NSG2 have opposite effects on synaptic plasticity, shedding light on their distinct molecular mechanisms.





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