Neuron Specific Gene family members NSG1 & NSG2 differentially affect long-term potentiation, learning and memory

Authors

Antonio D. Serrano Rodriguez, Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM
Amber Zimmerman, University of Pennsylvania, Philadelphia, PA
Sandy Wilson, Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM
David Linsebardt, Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM
Jonathan Brigman, Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM
Jason Weick, Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM

Document Type

Poster

Publication Date

3-22-2024

Abstract

Non-Expert Summary:

The neuron-specific gene family (NSG1-3) plays crucial roles in regulating the movement and processing of key proteins within neurons, particularly those involved in Alzheimer's disease and synaptic strength regulation. While NSG1 is known for its importance in proper synaptic function, NSG2's role is less understood. Surprisingly, deleting NSG2 selectively enhanced learning and memory, contrary to predictions. Electrophysiology experiments revealed NSG1 and NSG2 have opposite effects on synaptic plasticity, shedding light on their distinct molecular mechanisms.

Funding:

5R01NS116051-04

Recommended Citation

Serrano Rodriguez, Antonio D.; Amber Zimmerman; Sandy Wilson; David Linsebardt; Jonathan Brigman; and Jason Weick. "Neuron Specific Gene family members NSG1 & NSG2 differentially affect long-term potentiation, learning and memory." (2024). https://digitalrepository.unm.edu/hsc-bbhrd/190