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Late-life depression (LLD) is associated with elevated inflammatory markers, suggesting a possible mechanistic role and targets for treatment. We recruited 10 patients with late-life depression to receive 45 treatments of iTBS. Each participant underwent diffusion magnetic resonance spectroscopy (dMRS), an experimental sequence that detects changes in microglial activation. Preliminary results showed that iTBS may modulate inflammation through change of microglia conformation in the thalamus. Further work is needed to confirm findings.



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