Accelerated Intermittent Theta Burst Stimulation Modulates Microglial Activation in the Thalamus: Preliminary Data

Authors

Karen Luo, University of New Mexico, Department of Neurosciences
Binh Nguyen, University of New Mexico, Department of Neurosciences
Sarah Ward, University of New Mexico, Department of Neurosciences
Tessa Olmstead, University of New Mexico, Department of Psychiatry and Behavioral Sciences
Hans Van der Horn, University of New Mexico, Mind Research Network
Christopher Abbott, University of New Mexico, Department of Psychiatry and Behavioral Sciences
Andrei Vakhtin, University of New Mexico, Mind Research Network
Davin K. Quinn, University of New Mexico, Department of Psychiatry and Behavioral Sciences

Document Type

Poster

Publication Date

2-22-2024

Abstract

Late-life depression (LLD) is associated with elevated inflammatory markers, suggesting a possible mechanistic role and targets for treatment. We recruited 10 patients with late-life depression to receive 45 treatments of iTBS. Each participant underwent diffusion magnetic resonance spectroscopy (dMRS), an experimental sequence that detects changes in microglial activation. Preliminary results showed that iTBS may modulate inflammation through change of microglia conformation in the thalamus. Further work is needed to confirm findings.

Recommended Citation

Luo, Karen; Binh Nguyen; Sarah Ward; Tessa Olmstead; Hans Van der Horn; Christopher Abbott; Andrei Vakhtin; and Davin K. Quinn. "Accelerated Intermittent Theta Burst Stimulation Modulates Microglial Activation in the Thalamus: Preliminary Data." (2024). https://digitalrepository.unm.edu/hsc-bbhrd/187