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Cerebral small vessel disease (SVD) involves vascular pathological processes under hypoxic hypoperfusion that contributes to the endothelial dysfunction resulting in blood brain barrier (BBB) damage, brain white and grey matter lesions, and vascular cognitive impairment. We previously reported that activation of sphingosine-1-phosphate receptor 1 (S1PR1), using a selective S1PR1 agonist, SEW2871 (SEW) reversed the loss of BBB integrity. This study investigated the different doses of SEW2871, a S1PR1 agonist against neuropathological cascades involved in SVD.

FUNDING: This study is supported by a NIH/NINDS grant (1RF1NS110724) to Dr. Yi Yang



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