Sphingosine-1-phosphate receptor 1 agonist SEW2871 reduces BBB dysfunction and improves the cognitive impairment associated with cerebral small vessel disease

Authors

• Bushra Shal, Department of Neurology, University of New Mexico Health Science Center, Albuquerque, NM, 87111, United States
• Michael Griego, Department of Neurology, University of New Mexico Health Science Center, Albuquerque, NM, 87111, United States
• Yirong Yang, College of Pharmacy, University of New Mexico Health Science Center, Albuquerque, NM, 87111, United States
• Laurel Sillerud, Department of Neurology, University of New Mexico Health Science Center, Albuquerque, NM, 87111, United States
• Carlos Perez, Department of Neurology, University of New Mexico Health Science Center, Albuquerque, NM, 87111, United States
• Joanna McChriston, Department of Neurology, University of New Mexico Health Science Center, Albuquerque, NM, 87111, United States
• Haoran Deng, Department of Neurology, University of New Mexico Health Science Center, Albuquerque, NM, 87111, United States
• Haojie Chen, Department of Neurology, University of New Mexico Health Science Center, Albuquerque, NM, 87111, United States
• Yi Yang, Department of Neurology, University of New Mexico Health Science Center, Albuquerque, NM, 87111, United States

Document Type

Poster

Publication Date

3-22-2024

Abstract

Cerebral small vessel disease (SVD) involves vascular pathological processes under hypoxic hypoperfusion that contributes to the endothelial dysfunction resulting in blood brain barrier (BBB) damage, brain white and grey matter lesions, and vascular cognitive impairment. We previously reported that activation of sphingosine-1-phosphate receptor 1 (S1PR1), using a selective S1PR1 agonist, SEW2871 (SEW) reversed the loss of BBB integrity. This study investigated the different doses of SEW2871, a S1PR1 agonist against neuropathological cascades involved in SVD.

FUNDING: This study is supported by a NIH/NINDS grant (1RF1NS110724) to Dr. Yi Yang

Recommended Citation

Shal, Bushra; Michael Griego; Yirong Yang; Laurel Sillerud; Carlos Perez; Joanna McChriston; Haoran Deng; Haojie Chen; and Yi Yang. "Sphingosine-1-phosphate receptor 1 agonist SEW2871 reduces BBB dysfunction and improves the cognitive impairment associated with cerebral small vessel disease." (2024). https://digitalrepository.unm.edu/hsc-bbhrd/176