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Electroconvulsive therapy (ECT) is a highly effective treatment for major depressive disorder (MDD) yet many candidates for ECT treatment are reluctant due to the risk of cognitive side effects. It’s not currently known what underlies this cognitive impairment, but it has been proposed that long-term potentiation (LTP), which is a strengthening of neuronal connections underlying learning and memory, is disrupted during ECT treatment. We are measuring changes in LTP during ECT using electroencephalography (EEG).



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