Long-term Potentiation Disruption Underlying Cognitive Impairment in Electroconvulsive Therapy

Authors

Danielle Farrar, Department of Psychiatry and Behavioral Sciences, University of New Mexico Health Sciences Center
Karen Luo, Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center
Jude Chavez, Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center
Bibh Nguyen, Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center
Kevin Wilson, Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center
Sarah Ward, Center for Brain Recovery and Repair, University of New Mexico Health Sciences Center
Christopher Abbott, Department of Psychiatry and Behavioral Sciences, University of New Mexico Health Sciences Center

Document Type

Poster

Publication Date

3-22-2024

Abstract

Electroconvulsive therapy (ECT) is a highly effective treatment for major depressive disorder (MDD) yet many candidates for ECT treatment are reluctant due to the risk of cognitive side effects. It’s not currently known what underlies this cognitive impairment, but it has been proposed that long-term potentiation (LTP), which is a strengthening of neuronal connections underlying learning and memory, is disrupted during ECT treatment. We are measuring changes in LTP during ECT using electroencephalography (EEG).

Recommended Citation

Farrar, Danielle; Karen Luo; Jude Chavez; Bibh Nguyen; Kevin Wilson; Sarah Ward; and Christopher Abbott. "Long-term Potentiation Disruption Underlying Cognitive Impairment in Electroconvulsive Therapy." (2024). https://digitalrepository.unm.edu/hsc-bbhrd/161