Agonizing the 5-HT2c Receptor Attenuates Methamphetamine-Induced Conditioned Place Preference in Adolescent Male Rats
Methamphetamine use disorder (MUD) and other smulant use remains high in the Western area of the United States, with New Mexico having one of the highest smulant use percentages in adolescents, at 11.4%. Addionally, adolescence is a me of enhanced sensivity to drug reward and there are currently no FDA approved treatments for MUD. Therefore, there is a crical need to develop effecve intervenons for adolescents using methamphetamine. The present study ulized a condioned place preference paradigm (CPP) for determining if agonizing the serotonin-2C (5-HT2c) receptor atenuates expression of methamphetamine reward in adolescent Sprague-Dawley rats (PND 30). Rats were randomly assigned into four separate groups: 2c agonist-low/Meth, 2c-agonist high/Meth, Vehicle/Meth, and Vehicle/Saline. During condioning rats were given methamphetamine (1 mg/kg, i.p.) for 2 condioning sessions/day for 4 consecuve days following baseline preference tesng. Rats received injecons (s.c. ;0.3, 1 mg/kg) of the 5-HT2c agonist, CP809101, or a saline vehicle 30 minutes before final expression tesng. Similar to previous studies examining cocaine, rats that received the high dose and low dose of CP809101 demonstrated reduced expression of methamphetamine-induced CPP. These findings suggest that agonizing the 5-HT2c receptor may be an effecve pharmacotherapy intervenon for those diagnosed with MUD.
Reyna, Nicole C. and Nathan S. Pentkowski. "Agonizing the 5-HT2c Receptor Attenuates Methamphetamine-Induced Conditioned Place Preference in Adolescent Male Rats." (2023). https://digitalrepository.unm.edu/hsc-bbhrd/118
Poster presented at the Brain & Behavioral Health Research Day 2023