Agonizing the 5-HT2c Receptor Attenuates Methamphetamine-Induced Conditioned Place Preference in Adolescent Male Rats

Authors

Nicole C. Reyna
Nathan S. Pentkowski

Document Type

Poster

Publication Date

3-31-2023

Abstract

Methamphetamine use disorder (MUD) and other s􀆟mulant use remains high in the Western area of the United States, with New Mexico having one of the highest s􀆟mulant use percentages in adolescents, at 11.4%. Addi􀆟onally, adolescence is a 􀆟me of enhanced sensi􀆟vity to drug reward and there are currently no FDA approved treatments for MUD. Therefore, there is a cri􀆟cal need to develop effec􀆟ve interven􀆟ons for adolescents using methamphetamine. The present study u􀆟lized a condi􀆟oned place preference paradigm (CPP) for determining if agonizing the serotonin-2C (5-HT2c) receptor atenuates expression of methamphetamine reward in adolescent Sprague-Dawley rats (PND 30). Rats were randomly assigned into four separate groups: 2c agonist-low/Meth, 2c-agonist high/Meth, Vehicle/Meth, and Vehicle/Saline. During condi􀆟oning rats were given methamphetamine (1 mg/kg, i.p.) for 2 condi􀆟oning sessions/day for 4 consecu􀆟ve days following baseline preference tes􀆟ng. Rats received injec􀆟ons (s.c. ;0.3, 1 mg/kg) of the 5-HT2c agonist, CP809101, or a saline vehicle 30 minutes before final expression tes􀆟ng. Similar to previous studies examining cocaine, rats that received the high dose and low dose of CP809101 demonstrated reduced expression of methamphetamine-induced CPP. These findings suggest that agonizing the 5-HT2c receptor may be an effec􀆟ve pharmacotherapy interven􀆟on for those diagnosed with MUD.

Comments

Poster presented at the Brain & Behavioral Health Research Day 2023

Recommended Citation

Reyna, Nicole C. and Nathan S. Pentkowski. "Agonizing the 5-HT2c Receptor Attenuates Methamphetamine-Induced Conditioned Place Preference in Adolescent Male Rats." (2023). https://digitalrepository.unm.edu/hsc-bbhrd/118